Liquid filled and sealed hard gelatin capsules

Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration.

The encapsulation of liquids and semi-solids provides solutions for convenient delivery through improved oral absorption of poorly water-soluble drugs. In addition, low dose (content uniformity), highly potent (containment), low melting point drugs, those with a critical stability profile and those for which a delayed release is required are candidates for liquid or semi-solid formulations. Bot...

Filling two-piece hard gelatin capsules with liquids

Manufacturing and Quality Control of Liquid-Filled Two-piece Hard Capsules

Gas-phase distribution and emission of chloropicrin applied in gelatin capsules to soil columns.

Chloropicrin (CP) is highly volatile and may pose strong exposure risks for humans and the environment. A gelatin capsule formulation was developed to reduce atmospheric CP emissions and to improve application safety. The objective of this study was to determine the distribution, atmospheric emissions, and soil residual of CP after application in gelatin capsules to soil columns. Two treatments...

Capsules and It ’ S Technology : an Overview

727 Abstract: The gelatin cap-sule shell may be soft or hard depending on their formulation. Capsules are intended to be swallowed whole by the patient. In instances where patients (especially children) are unable to swallow capsules, the contents of the capsule can be removed and added (e.g., sprinkled) on soft food immediately before ingestion. In the manufacture of pharmaceuticals, encapsula...